The rate and speed with which cancer biology discoveries translate into clinical practice
have importance for oncologists, researchers, and policy makers. A prior study found
that among 101 science articles claiming a highly promising result for clinical translation,
only 19 of 101 (18.8%) interventions had positive randomized trials, whereas five
had been licensed for clinical use with a median follow-up of 12 years.
1
To read this article in full you will need to make a payment
Subscribe to Annals of Oncology
Already a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
References
- Translation of highly promising basic science research into clinical applications.Am J Med. 2003; 114: 477-484
- Treatment of inoperable gastrointestinal stromal tumor (GIST) with Imatinib (Glivec, Gleevec).Med Klin (Munich). 2002; 97: 28-30
- New anti-cancer role for PDK1 inhibitors: preventing resistance to tamoxifen.Biochem J. 2009; 417: e5-e7
- Zentralbl Gynakol. 2006; 128: 23-26
- Histological analysis of defective colonic healing as a result of angiostatin treatment.Exp Mol Pathol. 2003; 75: 119-123
- STD vaccine breakthrough. Cervarix would prevent human papilloma virus which can lead to cervical cancer; FDA approval anticipated.Health News Walth Mass. 2005; 11: 6-7
- Vopr Onkol. 2001; 47: 195-199
- Interference with EGFR signaling: paradigm for improving radiation response in cancer treatment.Expert Rev Anticancer Ther. 2002; 2: 461-471
- Radiation response modification following molecular inhibition of epidermal growth factor receptor signaling.Semin Radiat Oncol. 2001; 11: 281-289
- The role of oxaliplatin in the management of upper gastrointestinal tract malignancies.Colorectal Dis. 2003; 5: 36-44
- Dendritic cells: friend or foe in autoimmunity?.Rheum Dis Clin North Am. 2004; 30: 115-134
- The potential of PARP inhibitors in genetic breast and ovarian cancers.Ann N Y Acad Sci. 2008; 1138: 136-145
- Bull Cancer (Paris). 2007; 94: 23-31
- Efficient nonviral transfection of dendritic cells and their use for in vivo immunization.Nat Biotechnol. 2000; 18: 1273-1278
- BCL-2 in the crosshairs: tipping the balance of life and death.Cell Death Differ. 2006; 13: 1339-1350
- Effective gene-virotherapy for complete eradication of tumor mediated by the combination of hTRAIL (TNFSF10) and plasminogen k5.Mol Ther. 2005; 11: 531-541
- Tidsskr Den Nor Laegeforening. 1999; 119: 2510-2514
- Viral and non-viral vectors in gene therapy: technology development and clinical trials.Technol Cancer Res Treat. 2003; 2: 471-486
Article Info
Publication History
Published online: October 29, 2020
Identification
Copyright
© 2020 European Society for Medical Oncology. Published by Elsevier Ltd. All rights reserved.