How often do highly promising cancer biology discoveries translate into effective treatments?

Published:October 29, 2020DOI:https://doi.org/10.1016/j.annonc.2020.10.484
      The rate and speed with which cancer biology discoveries translate into clinical practice have importance for oncologists, researchers, and policy makers. A prior study found that among 101 science articles claiming a highly promising result for clinical translation, only 19 of 101 (18.8%) interventions had positive randomized trials, whereas five had been licensed for clinical use with a median follow-up of 12 years.
      • Contopoulos-Ioannidis D.G.
      • Ntzani E.
      • Ioannidis J.P.A.
      Translation of highly promising basic science research into clinical applications.
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